The card, which takes place September 29 from Sacramento, California, will be shown live on Showtime. Strikeforce officials and Melendez each confirmed the bout via Twitter.
Melendez (21-2) downed Josh Thomson earlier this year for his seventh straight win. He is 11-1 in a dozen fights under the Strikeforce banner.
Healy, a veteran of the sport, carries a record of 28-16 into the fight. Healy defeated Mizuto Hirota for his fifth consecutive victory recently, improving to 8-1 in his last nine fights and 6-1 with Strikeforce.
The card will also feature Daniel Cormier, though no opponent has been signed to face “DC” yet.
Photo credit: Esther Lin/STRIKEFORCE