Lightweights Melvin Guillard and Jamie Varner will each try to rebound from losses when they face each other in December at The Ultimate Fighter 16 Finale.
The bout, which was announced by UFC officials on Thursday, will likely end up on the main card for the evening.
Guillard (30-11-2) was defeated by Donald Cerrone earlier this year, dropping him to 1-3 and 11-7 inside the Octagon.
Varner (20-7-1) made his triumphant return to the UFC by stunning Edson Barboza, was stopped by Joe Lauzon in his last fight. He is 2-2 in his UFC career.